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Long-term safety remains a crucial area of focus, particularly in understanding the implications of senescent cell clearance over extended periods

Risk assesment of mycotoxins for the consumer

Ethics declarations Ethics declarations All animal work in this study was performed in accordance with the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, USA) and approved by the Animal Ethical and Experimental Committee of Nanjing University of Chinese Medicine (ACU-15 & ACU170501)

Probiotics have been used in connection with dietary interventions leading to improvements in mood and inflammation in human trials (Kazemi et al., 2019)

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Preclinical studies in animal models, such as EAE and DSS-induced colitis, have consistently demonstrated the efficacy of targeting metabolic nodes like mTOR, AMPK, HIF-1, and PKM2 in rebalancing Th17/Treg responses